Due to the recent development of successful new screening technologies, there has been a dramatic increase in interest in ion channels as drug targets. The proliferation of ion channel screening programmes requires electrophysiology support for hit validation, potency determination, selectivity profiling and lead optimization. NeuroSolutions Ltd. aims to provide vital world class electrophysiological support for ion channel drug discovery programmes.

In vitro electrophysiology at NeuroSolutions Ltd. includes:

• Whole-cell patch clamp recordings and single channel recordings from cell lines stably expressing ligand-gated channels or voltage-gated channels
• Perforated patch and intracellular recordings for G-protein coupled receptors and signal transduction pathways
• Whole-cell patch clamp recordings and single channel recordings from primary neuronal cultures
• Two-electrode voltage clamp recordings and macropatch recordings from Xenopus oocytes heterologously expressing ion channels

NeuroSolutions' expert ion channel pharmacologists can provide important information on compound potency, mechanism of action and selectivity:

• Concentration-dependence
• Mechanism of action
• State-dependence
• Kinetics of modulation
• Site of compound interaction
• Single channel analysis
• hERG selectivity