Slice electrophysiology can be used to identify specific drug targets, evaluate efficacy, investigate mechanism of action and thus aid assay development to translate such findings into high and medium throughput screens. We can also deconvolute hits from such screening strategies, establishing the nature of native targets..

Slice electrophysiology at NeuroSolutions Ltd. includes:

• Blind or infra-red visualised patch clamp recordings from brain and spinal cord slices
• Extracellular recordings, including measurement of long-term potentiation in hippocampal slices using field potential recordings

NeuroSolutions' slice experts can provide a broad range of pharmacological and physiological data using the following techniques:

• Current/voltage-clamp recordings
• Perforated patch recordings
• Pre-/post-synaptic activity
• Paired recordings
• Field potential recordings
• Quantitative/single-cell RT-PCR